The Cleavage: ADARB2

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Adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)

Identifiers

Symbols

ADARB2; ADAR3; FLJ25034; FLJ36975; RED2; hRED2

External IDs

OMIM: 602065 MGI: 2151118 HomoloGene: 10276

Gene ontology
Molecular function:	• RNA binding • double-stranded RNA binding • single-stranded RNA binding • adenosine deaminase activity • zinc ion binding • hydrolase activity • metal ion binding
Cellular component:	• intracellular • nucleus
Biological process:	• mRNA editing • RNA processing • mRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018702 (mRNA)

NP_061172 (protein)

NM_052977 (mRNA)

NP_443209 (protein)

Location

Chr 10: 1.22 - 1.77 Mb

Chr 13: 8.2 - 8.76 Mb

Pubmed search

[1]

[2]

Adenosine deaminase, RNA-specific, B2 (RED2 homolog rat), also known as ADARB2, is a human gene.^[1]

RNA-editing deaminase-2 (RED2, or ADARB2) is a member of the double-stranded RNA (dsRNA) adenosine deaminase family of RNA-editing enzymes. Adenosine deamination of pre-mRNA results in a change in the amino acid sequence of the gene product, which differs from that predicted by the genomic DNA sequence. Other members of this family include DRADA (ADAR; MIM 601059) and RED1 (ADARB1; MIM 601218) (Mittaz et al., 1997 [PubMed 9272162]).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b "Entrez Gene: ADARB2 adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=105.

[edit] Further reading

Valenzuela A, Blanco J, Callebaut C, et al. (1997). "HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26.". Adv. Exp. Med. Biol. 421: 185-92. PMID 9330696.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.

Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413.

Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.

Herrera C, Morimoto C, Blanco J, et al. (2001). "Comodulation of CXCR4 and CD26 in human lymphocytes.". J. Biol. Chem. 276 (22): 19532-9. doi:10.1074/jbc.M004586200. PMID 11278278.

Blanco J, Valenzuela A, Herrera C, et al. (2000). "The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression.". FEBS Lett. 477 (1-2): 123-8. PMID 10899322.

Chen CX, Cho DS, Wang Q, et al. (2000). "A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains.". RNA 6 (5): 755-67. PMID 10836796.

Mittaz L, Antonarakis SE, Higuchi M, Scott HS (1997). "Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15.". Hum. Genet. 100 (3-4): 398-400. PMID 9272162.

Valenzuela A, Blanco J, Callebaut C, et al. (1997). "Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles.". J. Immunol. 158 (8): 3721-9. PMID 9103436.

Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807-28. PMID 8889549.